Some of the more common genetic mutations in VKORC1, their e

Some of the more common genetic mutations in VKORC1, their effect on warfarin resistance and the rec… Show more Some of the more common genetic mutations in VKORC1, their effect on warfarin resistance and the recommended daily dosage are detailed below: wild type – A41S- Resistance level- Moderate. Daily dose (mg) – 4-6 wild type – V66M- Resistance level- Major. Daily dose (mg) – 16 wild type – R48G- Resistance level- Major. Daily dose (mg) – 31 wild type – L28R- Resistance level- Severe. Daily dose (mg) – >45 wild type – V454- Resistance level- Severe. Daily dose (mg) – cannot reach target level The protein sequences that you have obtained start at amino acid position 40. What daily dose of warfarin should be prescribed to patient X and why? [3] • Show less

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